Immune cells called regulatory T cells accumulate in fat during ageing. The anti-inflammatory activity of these cells worsens age-associated defects in metabolism, in contrast to its effect in obesity. See Letter p.137
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References
Osborn, O. & Olefsky, J. M. Nature Med. 18, 363–374 (2012).
Bapat, S. P. et al. Nature 528, 137–141 (2015).
Feuerer, M. et al. Nature Med. 15, 930–939 (2009).
Winer, S. et al. Nature Med. 15, 921–929 (2009).
Kolodin, D. et al. Cell Metab. 21, 543–557 (2015).
Cipolletta, D., Cohen, P., Spiegelman, B. M., Benoist, C. & Mathis, D. Proc. Natl Acad. Sci. USA 112, 482–487 (2015).
Cipolletta, D. et al. Nature 486, 549–553 (2012).
Vasanthakumar, A. et al. Nature Immunol. 16, 276–285 (2015).
Lumeng, C. N. et al. J. Immunol. 187, 6208–6216 (2011).
Brestoff, J. R. et al. Nature 519, 242–246 (2015).
Lee, M.-W. et al. Cell 160, 74–87 (2015).
Lumeng, C. N. & Saltiel, A. R. J. Clin. Invest. 121, 2111–2117 (2011).
Wernstedt Asterholm, I. et al. Cell Metab. 20, 103–118 (2014).
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Maillard, I., Saltiel, A. Inflammation keeps old mice healthy. Nature 528, 44–46 (2015). https://doi.org/10.1038/nature15648
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DOI: https://doi.org/10.1038/nature15648
