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Homed to the hideout

Some Staphylococcus aureus bacteria are thought to survive standard antibiotic treatment by 'hiding' in host cells. But an antibody–antibiotic conjugate has been developed that targets these bacteria in mouse models. See Article p.323

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Figure 1: Targeted intracellular antibiotic release.


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  1. Lehar, S. M. et al. Nature 527, 323–328 (2015).

    CAS  ADS  Article  Google Scholar 

  2. World Health Organization. Antimicrobial Resistance: Global Report on Surveillance (WHO, 2014).

  3. Lewis, K. Annu. Rev. Microbiol. 64, 357–372 (2010).

    CAS  Article  Google Scholar 

  4. Giang, I., Boland, E. L. & Poon, G. M. K. AAPS J. 16, 899–913 (2014).

    CAS  Article  Google Scholar 

  5. Joller, N. et al. Proc. Natl Acad. Sci. USA 107, 20441–20446 (2010).

    CAS  ADS  Article  Google Scholar 

  6. Yacoby, I. & Benhar, I. Infect. Disord. Drug Targets 7, 221–229 (2007).

    CAS  Article  Google Scholar 

  7. Conlon, B. P. et al. Nature 503, 365–370 (2013).

    CAS  ADS  Article  Google Scholar 

  8. Kaiser, P. et al. PLoS Biol. 12, e1001793 (2014).

    Article  Google Scholar 

  9. Porte, R. et al. Antimicrob. Agents Chemother. 59, 6064–6072 (2015).

    CAS  Article  Google Scholar 

  10. Iwase, T. et al. Nature 465, 346–349 (2010).

    CAS  ADS  Article  Google Scholar 

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Correspondence to Wolf-Dietrich Hardt.

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Hardt, WD. Homed to the hideout. Nature 527, 309–310 (2015).

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