Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Non-coding RNA

Antibiotic tricks a switch

A screen for compounds that block a bacterial biosynthetic pathway has uncovered an antibiotic lead that shuts off pathogen growth by targeting a molecular switch in a regulatory RNA structure. See Article p.672

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Metabolic-pathway blockade identifies an antibiotic.


  1. See all news & views


  1. Waksman, S. A. Mycologia 39, 565–569 (1947).

    CAS  Article  Google Scholar 

  2. Waksman, S. A. Science 118, 259–266 (1953).

    CAS  Article  ADS  Google Scholar 

  3. Howe, J. A. et al. Nature 526, 672–677 (2015).

    CAS  Article  ADS  Google Scholar 

  4. Infectious Diseases Society of America. Bad Bugs, No Drugs (IDSA, 2004).

  5. World Health Organization. Antimicrobial Resistance: Global Report on Surveillance (WHO, 2014).

  6. Matzner, D. & Mayer, G. J. Med. Chem. 58, 3275–3286 (2015).

    CAS  Article  Google Scholar 

  7. Dibrov, S. M. et al. J. Med. Chem. 57, 1694–1707 (2014).

    CAS  Article  Google Scholar 

  8. McCoy, L. S., Xie, Y. & Tor, Y. Wiley Interdisc. Rev. RNA 2, 209–232 (2011).

    CAS  Article  Google Scholar 

  9. Morris, K. V. & Mattick, J. S. Nature Rev. Genet. 15, 423–437 (2014).

    CAS  Article  Google Scholar 

  10. Taft, R. J., Pang, K. C., Mercer, T. R., Dinger, M. & Mattick, J. S. J. Pathol. 220, 126–139 (2010).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Thomas Hermann.

Related links

Related links

Related links in Nature Research

Antibiotics: An irresistible newcomer

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hermann, T. Antibiotic tricks a switch. Nature 526, 650–651 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing