Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Gene regulation

Expression feels two pulses

Single-cell analyses reveal that combinatorial changes in the intracellular locations of transcription factors can tune the expression of the factors' target genes in response to environmental stimuli. See Article p.54

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Interpreting transcription-factor pulses.


  1. 1.

    See all news & views


  1. 1

    Corrigan, A. M. & Chubb, J. R. Curr. Biol. 24, 205–211 (2014).

    CAS  Article  Google Scholar 

  2. 2

    Lin, Y., Sohn, C. H., Dalal, C. K., Cai, L. & Elowitz, M. B. Nature 527, 54–58 (2015).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Jacquet, M., Renault, G., Lallet, S., De Mey, J. & Goldbeter, A. J. Cell Biol. 161, 497–505 (2003).

    CAS  Article  Google Scholar 

  4. 4

    Hansen, A. S. & O'Shea, E. K. eLife 4, e06559 (2015).

    Article  Google Scholar 

  5. 5

    De Wever, V., Reiter, W., Ballarini, A., Ammerer, G. & Brocard, C. EMBO J. 24, 4115–4123 (2005).

    CAS  Article  Google Scholar 

  6. 6

    Drengstig, T., Ueda, H. R. & Ruoff, P. J. Phys. Chem. B 112, 16752–16758 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Hsu, C. et al. Nature Commun. 3, 682 (2012).

    Article  Google Scholar 

  8. 8

    Gerstner, W. Neural Netw. 14, 599–610 (2001).

    CAS  Article  Google Scholar 

  9. 9

    Liang, H. et al. Nature Commun. 5, 4048 (2014).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Attila Becskei.

Related links

Related links

Related links in Nature Research

Systems biology: Defiant daughters and coordinated cousins

Gene regulation: Fine-tuned amplification in cells

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Baudrimont, A., Becskei, A. Expression feels two pulses. Nature 527, 46–47 (2015).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing