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Immunology

Caspase target drives pyroptosis

Inflammatory caspase proteins help to control pathogen replication by triggering pyroptotic cell death. It now emerges that cleavage of the caspase substrate gasdermin D is sufficient to induce pyroptosis. See Articles p.660 & p.666

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Figure 1: Gasdermin D cleavage initiates pyroptosis during inflammasome activation.

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References

  1. 1

    Shi, J. et al. Nature 526, 660–665 (2015).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Kayagaki, N. et al. Nature 526, 666–671 (2015).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Martinon, F., Burns, K. & Tschopp, J. Mol. Cell 10, 417–426 (2002).

    CAS  Article  Google Scholar 

  4. 4

    Shi, J. et al. Nature 514, 187–192 (2014).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Cookson, B. T. & Brennan, M. A. Trends Microbiol. 9, 113–114 (2001).

    CAS  Article  Google Scholar 

  6. 6

    Rubartelli, A., Cozzolino, F., Talio, M. & Sitia, R. EMBO J. 9, 1503–1510 (1990).

    CAS  Article  Google Scholar 

  7. 7

    Agard, N. J., Maltby, D. & Wells, J. A. Mol. Cell. Proteomics 9, 880–893 (2010).

    CAS  Article  Google Scholar 

  8. 8

    Ruge, F. et al. J. Invest. Dermatol. 131, 572–579 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Segawa, K. et al. Science 344, 1164–1168 (2014).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Coleman, M. L. et al. Nature Cell Biol. 3, 339–345 (2001).

    CAS  Article  Google Scholar 

  11. 11

    Sebbagh, M. et al. Nature Cell Biol. 3, 346–352 (2001).

    CAS  Article  Google Scholar 

  12. 12

    Cai, Z. et al. Nature Cell Biol. 16, 55–65 (2014).

    CAS  Article  Google Scholar 

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Correspondence to Petr Broz.

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Broz, P. Caspase target drives pyroptosis. Nature 526, 642–643 (2015). https://doi.org/10.1038/nature15632

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