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Caspase target drives pyroptosis

Inflammatory caspase proteins help to control pathogen replication by triggering pyroptotic cell death. It now emerges that cleavage of the caspase substrate gasdermin D is sufficient to induce pyroptosis. See Articles p.660 & p.666

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Figure 1: Gasdermin D cleavage initiates pyroptosis during inflammasome activation.


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Correspondence to Petr Broz.

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Broz, P. Caspase target drives pyroptosis. Nature 526, 642–643 (2015).

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