Extended Data Figure 7: Bcl11a enhancer screen analyses. | Nature

Extended Data Figure 7: Bcl11a enhancer screen analyses.

From: BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Extended Data Figure 7

a, NGG sgRNA representation in plasmid pool and cells at conclusion of experiment (left), and in εy:mCherry-high and εy:mCherry-low pools (right), with dotted lines at x = y and x = 8y. b, Quantile–quantile plots of NGG sgRNA εy enrichment scores. c, Cellular dropout scores of NGG sgRNAs relative to genomic cleavage position and repetitive elements. Non-targeting sgRNAs are pseudo-mapped with 5 bp spacing. d, Correlation between cellular dropout and εy enrichment scores.

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