Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cardiac biology

A protein for healing infarcted hearts

Human heart tissue has minimal ability to regenerate following injury. But the protein Fstl1, which is normally expressed in the heart's epicardial region, has now been shown to induce regeneration following heart attack. See Article p.479

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Patched up to heal.


  1. See all news & views


  1. Bergmann, O. et al. Science 324, 98–102 (2009).

    Article  ADS  CAS  Google Scholar 

  2. Laflamme, M. A. & Murry, C. E. Nature 473, 326–335 (2011).

    Article  ADS  CAS  Google Scholar 

  3. Chong, J. J. et al. Nature 510, 273–277 (2014).

    Article  ADS  CAS  Google Scholar 

  4. Menasché, P. et al. Eur. Heart J. 36, 2011–2017 (2015).

    Article  Google Scholar 

  5. Wei, K. et al. Nature 525, 479–485 (2015).

    Article  ADS  CAS  Google Scholar 

  6. Sylva, M., Moorman, A. F. M. & van den Hoff, M. J. B. Birth Defects Res. C 99, 61–69 (2013).

    Article  CAS  Google Scholar 

  7. Miyamae, T. et al. J. Immunol. 177, 4758–4762 (2006).

    Article  CAS  Google Scholar 

  8. Ogura, Y. et al. Circulation 126, 1728–1738 (2012).

    Article  Google Scholar 

  9. Mercola, M., Ruiz-Lozano, P. & Schneider, M. D. Genes Dev. 25, 299–309 (2011).

    Article  CAS  Google Scholar 

  10. van Wijk, B., Gunst, Q. D., Moorman, A. F. M. & van den Hoff, M. J. B. PLoS ONE 7, e44692 (2012).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Gordana Vunjak-Novakovic.

Related links

Related links

Related links in Nature Research

Regenerative biology: Neuregulin 1 makes heart muscle

Cardiac biology: Cell plasticity helps hearts to repair

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vunjak-Novakovic, G. A protein for healing infarcted hearts. Nature 525, 461–462 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing