Human heart tissue has minimal ability to regenerate following injury. But the protein Fstl1, which is normally expressed in the heart's epicardial region, has now been shown to induce regeneration following heart attack. See Article p.479
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Bergmann, O. et al. Science 324, 98–102 (2009).
Laflamme, M. A. & Murry, C. E. Nature 473, 326–335 (2011).
Chong, J. J. et al. Nature 510, 273–277 (2014).
Menasché, P. et al. Eur. Heart J. 36, 2011–2017 (2015).
Wei, K. et al. Nature 525, 479–485 (2015).
Sylva, M., Moorman, A. F. M. & van den Hoff, M. J. B. Birth Defects Res. C 99, 61–69 (2013).
Miyamae, T. et al. J. Immunol. 177, 4758–4762 (2006).
Ogura, Y. et al. Circulation 126, 1728–1738 (2012).
Mercola, M., Ruiz-Lozano, P. & Schneider, M. D. Genes Dev. 25, 299–309 (2011).
van Wijk, B., Gunst, Q. D., Moorman, A. F. M. & van den Hoff, M. J. B. PLoS ONE 7, e44692 (2012).
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Vunjak-Novakovic, G. A protein for healing infarcted hearts. Nature 525, 461–462 (2015). https://doi.org/10.1038/nature15217