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Cancer

Mutant p53 and chromatin regulation

The finding that genes encoding enzymes that modify histone proteins are among the targets of certain mutant forms of the p53 protein sheds light on how these mutations cause cancer beyond p53 inactivation. See Article p.206

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Figure 1: Gaining on p53.

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Correspondence to Carol Prives or Scott W. Lowe.

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Prives, C., Lowe, S. Mutant p53 and chromatin regulation. Nature 525, 199–200 (2015). https://doi.org/10.1038/nature15212

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