Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


A moving target


An in silico, three-dimensional model of tumour evolution suggests that cell motility is a key factor in the initial growth of a tumour mass. The model also reveals the dynamics of mutation spread. See Letter p.261

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Motility helps to explain tumour dynamics.


  1. See all news & views


  1. Waclaw, B. et al. Nature 525, 261–264 (2015).

    ADS  CAS  Article  Google Scholar 

  2. Thalhauser, C. J., Lowengrub, J. S., Stupack, D. & Komarova, N. L. Biol. Direct 5, 21 (2010).

    Article  Google Scholar 

  3. Michor, F., Iwasa, Y., Rajagopalan, H., Lengauer, C. & Nowak, M. A. Cell Cycle 3, 356–360 (2004).

    Article  Google Scholar 

  4. Komarova, N. L. Bull. Math. Biol. 68, 1573–1599 (2006).

    MathSciNet  Article  Google Scholar 

  5. Komarova, N. L., Shahriyari, L. & Wodarz, D. J. R. Soc. Interface 11, 20140014 (2014).

    Article  Google Scholar 

  6. Durrett, R. & Moseley, S. Ann. Appl. Probab. 25, 104–115 (2015).

    MathSciNet  PubMed  PubMed Central  Google Scholar 

  7. Komarova, N. L. Proc. Natl Acad. Sci. USA 111, 10789–10795 (2014).

    ADS  CAS  Article  Google Scholar 

  8. Haber, D. A. & Settleman, J. Nature 446, 145–146 (2007).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Natalia L. Komarova.

Related links

Related links

Related links in Nature Research

Cancer: Calculated treatment

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Komarova, N. A moving target. Nature 525, 198–199 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer