An in silico, three-dimensional model of tumour evolution suggests that cell motility is a key factor in the initial growth of a tumour mass. The model also reveals the dynamics of mutation spread. See Letter p.261
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Komarova, N. A moving target. Nature 525, 198–199 (2015). https://doi.org/10.1038/nature15210
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DOI: https://doi.org/10.1038/nature15210
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Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
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