An in silico, three-dimensional model of tumour evolution suggests that cell motility is a key factor in the initial growth of a tumour mass. The model also reveals the dynamics of mutation spread. See Letter p.261
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
Nature Communications Open Access 23 February 2017
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Waclaw, B. et al. Nature 525, 261–264 (2015).
Thalhauser, C. J., Lowengrub, J. S., Stupack, D. & Komarova, N. L. Biol. Direct 5, 21 (2010).
Michor, F., Iwasa, Y., Rajagopalan, H., Lengauer, C. & Nowak, M. A. Cell Cycle 3, 356–360 (2004).
Komarova, N. L. Bull. Math. Biol. 68, 1573–1599 (2006).
Komarova, N. L., Shahriyari, L. & Wodarz, D. J. R. Soc. Interface 11, 20140014 (2014).
Durrett, R. & Moseley, S. Ann. Appl. Probab. 25, 104–115 (2015).
Komarova, N. L. Proc. Natl Acad. Sci. USA 111, 10789–10795 (2014).
Haber, D. A. & Settleman, J. Nature 446, 145–146 (2007).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Komarova, N. A moving target. Nature 525, 198–199 (2015). https://doi.org/10.1038/nature15210
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature15210
This article is cited by
-
Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
Nature Communications (2017)