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Molecular biology

Unequal opportunity during class switching

The DNA breakage-and-repair mechanism that generates antibodies of different classes has, in theory, a 50% chance of occurring correctly. But this recombination turns out to be heavily biased towards productive events. See Letter p.134

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Figure 1: Biased recombination.


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Correspondence to Javier M. Di Noia.

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Di Noia, J. Unequal opportunity during class switching. Nature 525, 44–45 (2015).

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