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Molecular biology

Unequal opportunity during class switching

Nature volume 525, pages 4445 (03 September 2015) | Download Citation

The DNA breakage-and-repair mechanism that generates antibodies of different classes has, in theory, a 50% chance of occurring correctly. But this recombination turns out to be heavily biased towards productive events. See Letter p.134

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Affiliations

  1. Javier M. Di Noia is at the Institut de Recherches Cliniques de Montréal and Department of Medicine, Université de Montréal, Montreal, Quebec H2W 1R7, Canada.

    • Javier M. Di Noia

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Correspondence to Javier M. Di Noia.

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DOI

https://doi.org/10.1038/nature15209

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