The DNA breakage-and-repair mechanism that generates antibodies of different classes has, in theory, a 50% chance of occurring correctly. But this recombination turns out to be heavily biased towards productive events. See Letter p.134
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Di Noia, J. Unequal opportunity during class switching. Nature 525, 44–45 (2015). https://doi.org/10.1038/nature15209
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DOI: https://doi.org/10.1038/nature15209
