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Neurodegeneration

Problems at the nuclear pore

Expansion of a repetitive DNA sequence is associated with neurodegeneration. Three studies identify genes involved in nuclear import and export that can mediate the toxicity this expansion causes. See Article p.56 & Letter p.129

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Figure 1: Models of G4C2-mediated neurotoxicity.

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Correspondence to Randal S. Tibbetts.

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Fox, B., Tibbetts, R. Problems at the nuclear pore. Nature 525, 36–37 (2015). https://doi.org/10.1038/nature15208

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