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Location affects sporulation

Monitored changes in the number of copies of a gene during DNA replication control the timing of sporulation in bacteria. This discovery links replication to the concept that a gene's location on a chromosome can influence cell traits.

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Figure 1: A genetic imbalance regulates sporulation.


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  1. Bremer, H. & Dennis, P. P. in Escherichia coli and Salmonella, Vol. 2 (ed. Neidhardt, F. C.) 1553–1569 (ASM Press, 1996).

    Google Scholar 

  2. Schmid, M. B. & Roth, J. R. J. Bacteriol. 169, 2872–2875 (1987).

    Article  CAS  Google Scholar 

  3. Sousa, C., De Lorenzo, V. & Cebollat, A. Microbiology 143, 2071–2078 (1997).

    Article  CAS  Google Scholar 

  4. Block, D. H. S., Hussein, R., Liang, L. W. & Lim, H. N. Nucleic Acids Res. 40, 8979–8992 (2012).

    Article  CAS  Google Scholar 

  5. Couturier, E. & Rocha, E. P. C. Mol. Microbiol. 59, 1506–1518 (2006).

    Article  CAS  Google Scholar 

  6. Narula, J. et al. Cell 162, 328–337 (2015).

    Article  CAS  Google Scholar 

  7. Grimshaw, C. E. et al. Biochemistry 3, 1365–1375 (1998).

    Article  Google Scholar 

  8. Levine, J. H., Fontes, M. E., Dworkin, J. & Elowitz, M. B. PLoS Biol. 10, e1001252 (2012).

    Article  CAS  Google Scholar 

  9. Veening, J. W., Murray, H. & Errington, J. Genes Dev. 23, 1959–1970 (2009).

    Article  CAS  Google Scholar 

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Correspondence to Beth A. Lazazzera or Diarmaid Hughes.

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Lazazzera, B., Hughes, D. Location affects sporulation. Nature 525, 42–43 (2015).

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