Monitored changes in the number of copies of a gene during DNA replication control the timing of sporulation in bacteria. This discovery links replication to the concept that a gene's location on a chromosome can influence cell traits.
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Bremer, H. & Dennis, P. P. in Escherichia coli and Salmonella, Vol. 2 (ed. Neidhardt, F. C.) 1553–1569 (ASM Press, 1996).
Schmid, M. B. & Roth, J. R. J. Bacteriol. 169, 2872–2875 (1987).
Sousa, C., De Lorenzo, V. & Cebollat, A. Microbiology 143, 2071–2078 (1997).
Block, D. H. S., Hussein, R., Liang, L. W. & Lim, H. N. Nucleic Acids Res. 40, 8979–8992 (2012).
Couturier, E. & Rocha, E. P. C. Mol. Microbiol. 59, 1506–1518 (2006).
Narula, J. et al. Cell 162, 328–337 (2015).
Grimshaw, C. E. et al. Biochemistry 3, 1365–1375 (1998).
Levine, J. H., Fontes, M. E., Dworkin, J. & Elowitz, M. B. PLoS Biol. 10, e1001252 (2012).
Veening, J. W., Murray, H. & Errington, J. Genes Dev. 23, 1959–1970 (2009).
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Lazazzera, B., Hughes, D. Location affects sporulation. Nature 525, 42–43 (2015). https://doi.org/10.1038/nature15207
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DOI: https://doi.org/10.1038/nature15207
