Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Regenerative biology

Maintaining liver mass

A previously under-appreciated subset of liver cells has been found to contribute to the day-to-day maintenance of liver mass in mice. The cells are induced and supported by signals from an adjacent vein. See Article p.180

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: A contributor to everyday liver regeneration.

Notes

  1. See all news & views

References

  1. Miyajima, A., Tanaka, M. & Itoh, T. Cell Stem Cell 14, 561–574 (2014).

    CAS  Article  Google Scholar 

  2. Wang, B., Zhao, L., Fish, M., Logan, C. Y. & Nusse, R. Nature 524, 180–185 (2015).

    CAS  Article  ADS  Google Scholar 

  3. Malato, Y. J. Clin. Invest. 121, 4850–4860 (2011).

    CAS  Article  Google Scholar 

  4. Tarlow, B. D. et al. Cell Stem Cell 15, 605–618 (2014).

    CAS  Article  Google Scholar 

  5. Yanger, K. et al. Cell Stem Cell 15, 340–349 (2014).

    CAS  Article  Google Scholar 

  6. Magami, Y. et al. Liver 22, 419–425 (2002).

    Article  Google Scholar 

  7. Benhamouche, S. et al. Dev. Cell 10, 759–770 (2006).

    CAS  Article  Google Scholar 

  8. Yang, J. et al. Hepatology 60, 964–976 (2014).

    CAS  Article  Google Scholar 

  9. Rompolas, P., Mesa, K. R. & Greco, V. Nature 502, 513–518 (2013).

    CAS  Article  ADS  Google Scholar 

  10. Sheng, X. R., Brawley, C. M. & Matunis, E. L. Cell Stem Cell 5, 191–203 (2009).

    CAS  Article  Google Scholar 

  11. Duncan, A. W. et al. Nature 467, 707–710 (2010).

    CAS  Article  ADS  Google Scholar 

  12. Huch, M. et al. Nature 494, 247–250 (2013).

    CAS  Article  ADS  Google Scholar 

  13. Suzuki, A., Sekiya, S., Büscher, D., Izpisúa Belmonte, J. C. & Taniguchi, H. Development 135, 1589–1595 (2008).

    CAS  Article  Google Scholar 

  14. Matsumoto, K., Yoshitomi, H., Rossant, J. & Zaret, K. S. Science 294, 559–563 (2001).

    CAS  Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kenneth S. Zaret.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zaret, K. Maintaining liver mass. Nature 524, 165–166 (2015). https://doi.org/10.1038/nature15201

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature15201

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing