Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
The table shows the predictive value of a PGC-trained polygenic risk score on the CONVERGE results. Predictive values are shown at varying P value thresholds (pT) from P ≤ 1 × 10−6 to 1 (that is, all results). P is the P value of the prediction and r2 is the amount of variance explained (thus the table shows that including all independent SNPs from the PGC study of MDD, irrespective of individual P value, explained 0.09% of MDD risk in CONVERGE.). The number of independent SNPs at each threshold is presented (No. SNPs); the significance of the observed fraction (%) demonstrating a consistent direction of effect was assessed by a one-sided binomial sign test.