Extended Data Figure 3: Manhattan and quantile quantile plots for melancholia. | Nature

Extended Data Figure 3: Manhattan and quantile quantile plots for melancholia.

From: Sparse whole-genome sequencing identifies two loci for major depressive disorder

Extended Data Figure 3

a, Manhattan plot of GWAS for melancholia using the MLMe method implemented in FastLMM on 9,846 samples (4,509 cases, 5,337 controls). b, Quantile–quantile plot of GWAS for melancholia; λ = 1.069, λ 1000 = 1.014. c, Regional association plot of GWAS hits on chromosome 10, focusing on top SNP rs80309727 at 5′ of SIRT1 gene, generated with LocusZoom.

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