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Cell biology

Surviving import failure

Two studies reveal that dysfunction in organelles called mitochondria causes the toxic accumulation of mitochondrial proteins in the cell's cytosolic fluid, and identify ways in which damage is mitigated. See Letters p.481 & p.485

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Figure 1: Effects of decreased mitochondrial-protein import.

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References

  1. Wang, X. & Chen, X. J. Nature 524, 481–484 (2015).

    Article  ADS  CAS  Google Scholar 

  2. Wrobel, L. et al. Nature 524, 485–488 (2015).

    Article  ADS  CAS  Google Scholar 

  3. Matsuo, Y. et al. Nature 505, 112–116 (2014).

    Article  ADS  Google Scholar 

  4. Le Tallec, B. et al. Mol. Cell 27, 660–674 (2007).

    Article  CAS  Google Scholar 

  5. Sammons, M. A., Samir, P. & Link, A. J. Biochem. Biophys. Res. Commun. 406, 13–19 (2011).

    Article  CAS  Google Scholar 

  6. Akerfelt, M., Morimoto, R. I. & Sistonen, L. Nature Rev. Mol. Cell Biol. 11, 545–555 (2010).

    Article  CAS  Google Scholar 

  7. Nargund, A. M., Pellegrino, M. W., Fiorese, C. J., Baker, B. M. & Haynes, C. M. Science 337, 587–590 (2012).

    Article  ADS  CAS  Google Scholar 

  8. Narendra, D. P. et al. PLoS Biol. 8, e1000298 (2010).

    Article  Google Scholar 

  9. Johnson, S. C. et al. Science 342, 1524–1528 (2013).

    Article  ADS  CAS  Google Scholar 

Download references

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Correspondence to Cole M. Haynes.

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Haynes, C. Surviving import failure. Nature 524, 419–420 (2015). https://doi.org/10.1038/nature14644

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