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Structural biology

Hypoxia response becomes crystal clear

The crystal structures of two proteins that respond to reduced tissue oxygen levels — hypoxia-inducible factors — provide insight into their function and reveal sites for rational drug design. See Article p.303

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Figure 1: The HIF-α–ARNT heterodimer off and on DNA.

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Correspondence to Ronen Marmorstein or M. Celeste Simon.

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Marmorstein, R., Simon, M. Hypoxia response becomes crystal clear. Nature 524, 298–299 (2015). https://doi.org/10.1038/nature14641

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