Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Hypoxia response becomes crystal clear

The crystal structures of two proteins that respond to reduced tissue oxygen levels — hypoxia-inducible factors — provide insight into their function and reveal sites for rational drug design. See Article p.303

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: The HIF-α–ARNT heterodimer off and on DNA.

Notes

  1. See all news & views

References

  1. Semenza, G. L. Cell 148, 399–408 (2012).

    Article  CAS  Google Scholar 

  2. Wu, D., Potluri, N., Lu, J., Kim, Y. & Rastinejad, F. Nature 524, 303–308 (2015).

    Article  ADS  CAS  Google Scholar 

  3. Scheuermann, T. H. et al. Proc. Natl Acad. Sci. USA 106, 450–455 (2009).

    Article  ADS  CAS  Google Scholar 

  4. Scheuermann, T. H. et al. Nature Chem. Biol. 9, 271–276 (2013).

    Article  CAS  Google Scholar 

  5. Lee, K. et al. Proc. Natl Acad. Sci. USA 106, 17910–17915 (2009).

    Article  ADS  CAS  Google Scholar 

  6. Huang, N. et al. Science 337, 189–194 (2012).

    Article  ADS  CAS  Google Scholar 

  7. Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E. & Zhao, B. Toxicol. Sci. 124, 1–22 (2011).

    Article  CAS  Google Scholar 

  8. Dioum, E. M. et al. Science 298, 2385–2387 (2002).

    Article  ADS  CAS  Google Scholar 

  9. Keith, B., Johnson, R. S. & Simon, M. C. Nature Rev. Cancer 12, 9–22 (2012).

    Article  CAS  Google Scholar 

  10. Li, Y. et al. Cell 147, 629–640 (2011).

    Article  CAS  Google Scholar 

  11. Ollerenshaw, M., Page, T., Hammonds, J. & Demaine, A. Cancer Genet. Cytogenet. 153, 122–126 (2004).

    Article  CAS  Google Scholar 

  12. Morris, M. R. et al. Anticancer Res. 29, 4337–4343 (2009).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Ronen Marmorstein or M. Celeste Simon.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Marmorstein, R., Simon, M. Hypoxia response becomes crystal clear. Nature 524, 298–299 (2015). https://doi.org/10.1038/nature14641

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature14641

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing