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Structural biology

Hypoxia response becomes crystal clear

Nature volume 524, pages 298300 (20 August 2015) | Download Citation

The crystal structures of two proteins that respond to reduced tissue oxygen levels — hypoxia-inducible factors — provide insight into their function and reveal sites for rational drug design. See Article p.303

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Author information

Affiliations

  1. Ronen Marmorstein is in the Abramson Family Cancer Research Institute, Departments of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

    • Ronen Marmorstein
  2. M. Celeste Simon is in the Abramson Family Cancer Research Institute, Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

    • M. Celeste Simon

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Corresponding authors

Correspondence to Ronen Marmorstein or M. Celeste Simon.

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DOI

https://doi.org/10.1038/nature14641

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