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Molecular biology

It takes two to untangle

Nature volume 524, pages 169–170 (2015)Cite this article

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Yeast require the enzyme Hsp104 to untangle protein aggregates, which arise in stressed or aged cells. Animals lack Hsp104, but it emerges that proteins of the DNAJ family of molecular chaperones can fulfil this role. See Letter p.251

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Figure 1: Protein disaggregation by DNAJ proteins.

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References

  1. Hartl, F. U., Bracher, A. & Hayer-Hartl, M. Nature 475, 324–332 (2011).

    Article  CAS  Google Scholar 

  2. Balch, W. E., Morimoto, R. I., Dillin, A. & Kelly, J. W. Science 319, 916–919 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Doyle, S. M., Genest, O. & Wickner, S. Nature Rev. Mol. Cell Biol. 14, 617–629 (2013).

    Article  CAS  Google Scholar 

  4. Kampinga, H. H. J. Cell Sci. 104, 11–17 (1993).

    CAS  PubMed  Google Scholar 

  5. Rampelt, H. et al. EMBO J. 31, 4221–4235 (2012).

    Article  CAS  Google Scholar 

  6. Nillegoda, N. et al. Nature 524, 247–251 (2015).

    Article  ADS  CAS  Google Scholar 

  7. Kampinga, H. H. & Craig, E. A. Nature Rev. Mol. Cell Biol. 11, 579–592 (2010).

    Article  CAS  Google Scholar 

  8. Haslbeck, M., Franzmann, T., Weinfurtner, D. & Buchner, J. Nature Struct. Mol. Biol. 12, 842–846 (2005).

    Article  CAS  Google Scholar 

  9. Wolozin, B. Mol. Neurodegen. 7, 56–68 (2012).

    Article  CAS  Google Scholar 

  10. McMahon, H. T. & Boucrot, E. Nature Rev. Mol. Cell Biol. 12, 517–533 (2011).

    Article  CAS  Google Scholar 

  11. Kakkar, V., Prins, L. C. & Kampinga, H. H. Curr. Top. Med. Chem. 12, 2479–2490 (2012).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Harm H. Kampinga is in the Department of Cell Biology, University Medical Center Groningen and University of Groningen, 9713 AV Groningen, the Netherlands.,

    Harm H. Kampinga

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  1. Harm H. Kampinga
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Correspondence to Harm H. Kampinga.

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Kampinga, H. It takes two to untangle. Nature 524, 169–170 (2015). https://doi.org/10.1038/nature14640

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