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Molecular biology

It takes two to untangle

Yeast require the enzyme Hsp104 to untangle protein aggregates, which arise in stressed or aged cells. Animals lack Hsp104, but it emerges that proteins of the DNAJ family of molecular chaperones can fulfil this role. See Letter p.251

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Figure 1: Protein disaggregation by DNAJ proteins.


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Correspondence to Harm H. Kampinga.

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Kampinga, H. It takes two to untangle. Nature 524, 169–170 (2015).

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