Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Molecular biology

It takes two to untangle

Yeast require the enzyme Hsp104 to untangle protein aggregates, which arise in stressed or aged cells. Animals lack Hsp104, but it emerges that proteins of the DNAJ family of molecular chaperones can fulfil this role. See Letter p.251

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Protein disaggregation by DNAJ proteins.

Notes

  1. See all news & views

References

  1. Hartl, F. U., Bracher, A. & Hayer-Hartl, M. Nature 475, 324–332 (2011).

    CAS  Article  Google Scholar 

  2. Balch, W. E., Morimoto, R. I., Dillin, A. & Kelly, J. W. Science 319, 916–919 (2008).

    ADS  CAS  Article  Google Scholar 

  3. Doyle, S. M., Genest, O. & Wickner, S. Nature Rev. Mol. Cell Biol. 14, 617–629 (2013).

    CAS  Article  Google Scholar 

  4. Kampinga, H. H. J. Cell Sci. 104, 11–17 (1993).

    CAS  PubMed  Google Scholar 

  5. Rampelt, H. et al. EMBO J. 31, 4221–4235 (2012).

    CAS  Article  Google Scholar 

  6. Nillegoda, N. et al. Nature 524, 247–251 (2015).

    ADS  CAS  Article  Google Scholar 

  7. Kampinga, H. H. & Craig, E. A. Nature Rev. Mol. Cell Biol. 11, 579–592 (2010).

    CAS  Article  Google Scholar 

  8. Haslbeck, M., Franzmann, T., Weinfurtner, D. & Buchner, J. Nature Struct. Mol. Biol. 12, 842–846 (2005).

    CAS  Article  Google Scholar 

  9. Wolozin, B. Mol. Neurodegen. 7, 56–68 (2012).

    CAS  Article  Google Scholar 

  10. McMahon, H. T. & Boucrot, E. Nature Rev. Mol. Cell Biol. 12, 517–533 (2011).

    CAS  Article  Google Scholar 

  11. Kakkar, V., Prins, L. C. & Kampinga, H. H. Curr. Top. Med. Chem. 12, 2479–2490 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Harm H. Kampinga.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kampinga, H. It takes two to untangle. Nature 524, 169–170 (2015). https://doi.org/10.1038/nature14640

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature14640

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing