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Genetics

Feedforward loop for diversity

Nature volume 523, pages 414–416 (2015)Cite this article

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DNA-sequence analysis suggests that genetic mutations arise at elevated rates in genomes harbouring high levels of heterozygosity — the state in which the two copies of a genetic region contain sequence differences. See Letter p.463

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Figure 1: Generating variation.

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References

  1. Sung, W. et al. Proc. Natl Acad. Sci. USA 109, 19339–19344 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Lynch, M. Proc. Natl Acad. Sci. USA 107, 961–968 (2010).

    Article  ADS  CAS  Google Scholar 

  3. Foster, P. L. Genes Genomes Genet. 3, 399–407 (2013).

    CAS  Google Scholar 

  4. Sung, W. et al. Mol. Biol. Evol. 32, 1672–1683 (2015).

    Article  CAS  Google Scholar 

  5. Schrider, D., Houle, D., Lynch, M. & Hahn, M. Genetics 194, 937–954 (2013).

    Article  CAS  Google Scholar 

  6. Yang, S. et al. Nature 523, 463–467 (2015).

    Article  ADS  CAS  Google Scholar 

  7. Arbeithuber, B., Betancourt, A. J., Ebner, T. & Tiemann-Boege, I. Proc. Natl Acad. Sci. USA 112, 2109–2114 (2015).

    Article  ADS  CAS  Google Scholar 

  8. Harris, K. & Nielsen, R. Genome Res. 24, 1445–1454 (2014).

    Article  CAS  Google Scholar 

  9. Lynch, M. et al. Genetics 198, 269–281 (2014).

    Article  Google Scholar 

  10. Amos, W. BioEssays 32, 82–90 (2010).

    Article  CAS  Google Scholar 

  11. Chen, X. & Zhang, J. Mol. Biol. Evol. 30, 1559–1562 (2013).

    Article  CAS  Google Scholar 

  12. Ossowski, S. et al. Science 327, 92–94 (2010).

    Article  ADS  CAS  Google Scholar 

  13. Lynch, M. & Walsh, J. B. Genetics and Analysis of Quantitative Traits (Sinauer, 1998).

    Google Scholar 

  14. Lynch, M. Genome Biol. Evol. 3, 1107–1118 (2011).

    Article  Google Scholar 

  15. Small, K. S., Brudno, M., Hill, M. M. & Sidow A. Proc. Natl Acad. Sci. USA 104, 5698–5703 (2007).

    Article  ADS  CAS  Google Scholar 

  16. Dey, A., Chan, C. K., Thomas, C. G. & Cutter, A. D. Proc. Natl Acad. Sci. USA 110, 11056–11060 (2013).

    Article  ADS  CAS  Google Scholar 

  17. Keightley, P. D., Ness, R. W., Halligan, D. L. & Haddrill, P. R. Genetics 196, 313–320 (2014).

    Article  CAS  Google Scholar 

  18. Venn, O. et al. Science 344, 1272–1275 (2014).

    Article  ADS  CAS  Google Scholar 

Download references

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  1. Michael Lynch is in the Department of Biology, Indiana University, Bloomington, Indiana 47405, USA.,

    Michael Lynch

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  1. Michael Lynch
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Correspondence to Michael Lynch.

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Lynch, M. Feedforward loop for diversity. Nature 523, 414–416 (2015). https://doi.org/10.1038/nature14634

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