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Ophthalmology

Cataracts dissolved

Mutations underlying hereditary cataracts in two families impair the function of an enzyme that synthesizes the lens molecule lanosterol. The finding may lead to non-surgical prevention and treatment of cataracts. See Letter p.607

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Figure 1: The eye lens.

Paul Fitzgerald/Ref. 16

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References

  1. Zhao, L. et al. Nature 523, 607–611 (2015).

    Article  ADS  CAS  Google Scholar 

  2. Brewster, D. Phil. Trans. R. Soc. Lond. 123, 323–332 (1833).

    Article  ADS  Google Scholar 

  3. Spemann, H. Vehr. Anat. Ges. 15, 61–79 (1901).

    Google Scholar 

  4. Zhang, T. et al. Hum. Mutat. 30, E603–E611 (2009).

    Article  Google Scholar 

  5. Renwick, J. H. & Lawler, S. D. Ann. Hum. Genet. 27, 67–84 (1963).

    Article  CAS  Google Scholar 

  6. Zelenka, P. S. & Piatigorsky, J. Proc. Natl Acad. Sci. USA 71, 1896–1900 (1974).

    Article  ADS  CAS  Google Scholar 

  7. Michael, R., van Marle, J., Vrensen, G. F. & van den Berg, T. J. Exp. Eye Res. 77, 93–99 (2003).

    Article  CAS  Google Scholar 

  8. Bloemendal, H. et al. Prog. Biophys. Mol. Biol. 86, 407–485 (2004).

    Article  CAS  Google Scholar 

  9. Benedek, G. B. Appl. Optics 10, 459–473 (1971).

    Article  ADS  CAS  Google Scholar 

  10. Shiels, A. & Hejtmancik, J. F. Clin. Genet. 84, 120–127 (2013).

    Article  CAS  Google Scholar 

  11. Rao, P. V., Huang, Q.-L., Horwitz, J. & Zigler, J. S. Jr Biochim. Biophys. Acta 1245, 439–447 (1995).

    Article  Google Scholar 

  12. Datiles, M. B. III et al. Arch. Ophthalmol. 126, 1687–1693 (2008).

    Article  Google Scholar 

  13. Moreau, K. L. & King, J. A. Trends Mol. Med. 18, 273–282 (2012).

    Article  CAS  Google Scholar 

  14. Taylor, H. R. Br. J. Ophthalmol. 84, 1–2 (2000).

    Article  CAS  Google Scholar 

  15. Kupfer, C. Invest. Ophthalmol. Vis. Sci. 28, 2–8 (1987).

    CAS  PubMed  Google Scholar 

  16. Sun, N., Shibata, B., Hess, J. F. & FitzGerald, P. G. Mol. Vis. 21, 428–442 (2015).

    PubMed  PubMed Central  Google Scholar 

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Correspondence to J. Fielding Hejtmancik.

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Hejtmancik, J. Cataracts dissolved. Nature 523, 540–541 (2015). https://doi.org/10.1038/nature14629

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