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Myeloid disease

Another action of a thalidomide derivative

Lenalidomide effectively treats a blood disorder caused by the 5q chromosomal deletion. A study shows that the drug binds to its target, CRBN, to promote the breakdown of an enzyme encoded by a gene in the 5q region. See Article p.183

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Figure 1: Thalidomide and its derivatives confer the substrate specificity of CRBN.

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Correspondence to Hiroshi Handa.

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Ito, T., Handa, H. Another action of a thalidomide derivative. Nature 523, 167–168 (2015). https://doi.org/10.1038/nature14628

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