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Systems biology

Network evolution hinges on history

Nature volume 523, pages 297–298 (2015)Cite this article

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The effects of mutations in proteins can depend on the occurrence of previous mutations. It emerges that such historical contingency is also important during the evolution of gene regulatory networks. See Letter p.361

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Figure 1: Not all evolutionary paths are possible.

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References

  1. Lehner, B. Trends Genet. 27, 323–331 (2011).

    Article  CAS  Google Scholar 

  2. Sorrells, T. R., Booth, L. N., Tuch, B. B. & Johnson, A. D. Nature 523, 361–365 (2015).

    Article  ADS  CAS  Google Scholar 

  3. Wright, S. Proc. VI Int. Congr. Genet. Vol 1, 356–366 (1932).

    Google Scholar 

  4. Harms, M. J. & Thornton, J. W. Nature Rev. Genet. 14, 559–571 (2013).

    Article  CAS  Google Scholar 

  5. DePristo, M. A., Weinreich, D. M. & Hartl, D. L. Nature Rev. Genet. 6, 678–687 (2005).

    Article  CAS  Google Scholar 

  6. Tsong, A. E., Tuch, B. B., Li, H. & Johnson, A. D. Nature 443, 415–420 (2006).

    Article  ADS  CAS  Google Scholar 

  7. Baker, C. R., Booth, L. N., Sorrells, T. R. & Johnson, A. D. Cell 151, 80–95 (2012).

    Article  CAS  Google Scholar 

  8. Yu, R. C. et al. Nature 456, 755–761 (2008).

    Article  ADS  CAS  Google Scholar 

  9. Tyson, J. J., Chen, K. C. & Novak, B. Curr. Opin. Cell Biol. 15, 221–231 (2003).

    Article  CAS  Google Scholar 

  10. Jiménez, A., Munteanu, A. & Sharpe, J. Proc. Natl Acad. Sci. USA 112, 2103–2108 (2015).

    Article  ADS  Google Scholar 

Download references

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Authors and Affiliations

  1. Aaron M. New and Ben Lehner are at the EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), 08003 Barcelona, and at the Universitat Pompeu Fabra, Barcelona, Spain.,

    Aaron M. New & Ben Lehner

  2. B.L. is also at the Institució Catalana de Recerca i Estudis Avançats, Barcelona.,

    Ben Lehner

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  1. Aaron M. New
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  2. Ben Lehner
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Correspondence to Ben Lehner.

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New, A., Lehner, B. Network evolution hinges on history. Nature 523, 297–298 (2015). https://doi.org/10.1038/nature14537

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