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Neurodegeneration

Evolved protection against human prions

A genetic variant of PrP, the protein that forms prions, confers protection against the human prion disease kuru by inhibiting the conversion of functional isoforms to the abnormal, disease-causing conformation. See Letter p.478

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Figure 1: Valine variants.

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Correspondence to Glenn Telling.

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Telling, G. Evolved protection against human prions. Nature 522, 423–424 (2015). https://doi.org/10.1038/nature14534

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