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Cancer

Precise control of localized signals

The tumour-suppressor protein PTEN is mostly found in the cell cytoplasm, tethered to endosome vesicles. This localization regulates the enzyme's activity towards specific lipids and influences its control of cell growth.

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Figure 1: Endosomal PTEN in PIP3 control.

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References

  1. Hollander, M. C., Blumenthal, G. M. & Dennis, P. A. Nature Rev. Cancer 11, 289–301 (2011).

    Article  CAS  Google Scholar 

  2. Naguib, A. et al. Mol. Cell 58, 255–268 (2015).

    Article  CAS  Google Scholar 

  3. Lee, J. O. et al. Cell 99, 323–334 (1999).

    Article  CAS  Google Scholar 

  4. Georgescu, M. M. et al. Cancer Res. 60, 7033–7038 (2000).

    CAS  PubMed  Google Scholar 

  5. Worby, C. A. & Dixon, J. E. Annu. Rev. Biochem. 83, 641–669 (2014).

    Article  CAS  Google Scholar 

  6. Bassi, C. et al. Science 341, 395–399 (2013).

    Article  ADS  CAS  Google Scholar 

  7. Hopkins, B. D. et al. Science 341, 399–402 (2013).

    Article  ADS  CAS  Google Scholar 

  8. Backer, J. M. Biochem. J. 410, 1–17 (2008).

    Article  CAS  Google Scholar 

  9. Byfield, M. P., Murray, J. T. & Backer, J. M. J. Biol. Chem. 280, 33076–33082 (2005).

    Article  CAS  Google Scholar 

  10. Huang, J. et al. Nature Commun. 3, 911 (2012).

    Article  ADS  Google Scholar 

  11. Iijima, M., Huang, Y. E., Luo, H. R., Vazquez, F. & Devreotes, P. N. J. Biol. Chem. 279, 16606–16613 (2004).

    Article  CAS  Google Scholar 

  12. Chew, C. L. et al. Cancer Discov. http://dx.doi.org/10.1158/2159-8290.CD-14-1347 (2015).

  13. Kofuji, S. et al. Cancer Discov. http://dx.doi.org/10.1158/2159-8290.CD-14-1329 (2015).

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Correspondence to Vuk Stambolic.

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Stambolic, V. Precise control of localized signals. Nature 522, 38–40 (2015). https://doi.org/10.1038/nature14531

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