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Opening LOX to metastasis


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New findings implicate the enzyme lysyl oxidase (LOX), secreted by oxygen-deprived breast cancer cells, in inducing bone lesions that precede and facilitate the spread of the cancer cells to the bone. See Letter p.106

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Figure 1: Pre-metastatic niche formation in bone.

Change history

  • 11 May 2023

    The article on which this News & Views commented, ‘The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase’, has now been retracted.


  1. See all news & views


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Correspondence to Neta Erez.

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Erez, N. Opening LOX to metastasis. Nature 522, 41–42 (2015).

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