Figure 1: Pre-metastatic niche formation in bone. | Nature

Figure 1: Pre-metastatic niche formation in bone.

From: Opening LOX to metastasis

Figure 1

a, Cox et al.2 find that breast tumour cells that are exposed to hypoxic conditions secrete the enzyme lysyl oxidase (LOX) into the bloodstream. b, In bone, LOX activates cells called osteoclasts to enhance bone breakdown, resulting in the formation of bone lesions. c, These lesions create a pre-metastatic niche: breast cancer cells from the original tumour that are disseminated by the circulation are able to occupy this niche and form a metastatic tumour.

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