Aggregates of α-synuclein protein can form in various cell types and cause different neurodegenerative disorders. The existence of strains with distinct structural conformations might explain this variability. See Letter p.340
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References
Lashuel, H. A., Overk, C. R., Oueslati, A. & Masliah, E. Nature Rev. Neurosci. 14, 38–48 (2013).
Brück, D., Wenning, G. K., Stefanova, N. & Fellner, L. Neurobiol. Dis. http://dx.doi.org/10.1016/j.nbd.2015.03.003 (2015).
Peelaerts, W. et al. Nature 522, 340–344 (2015).
Kramer, M. L. & Schultz-Schaeffer, W. J. J. Neurosci. 27, 1405–1410 (2007).
Kim, W. S., Kågedal, K. & Halliday, G. M. Alz. Res. Ther. 6, 73 (2014).
Brettschneider, J., Del Tredici, K., Lee, V. M.-Y. & Trojanowski, J. Q. Nature Rev. Neurosci. 16, 109–120 (2015).
Bousset, L. et al. Nature Commun. 4, 2575 (2013).
Lashuel, H. A., LaBrenz, S. R., Woo, L., Serpell, L. C. & Kelly, J. W. J. Am. Chem. Soc. 122, 5262–5277 (2000).
Luk, K. C. et al. Science 338, 949–953 (2012).
Mollenhauer, B., El-Agnaf, O. M. A., Marcus, K., Trenkwalder, C. & Schlossmacher, M. G. Biomark. Med. 4, 683–699 (2010).
Lee, H.-J., Bae, E.-J. & Lee, S.-J. Nature Rev. Neurol. 10, 92–98 (2014).
Lu, J.-X. et al. Cell 154, 1257–1268 (2013).
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Lee, SJ., Masliah, E. Aggregates feel the strain. Nature 522, 296–297 (2015). https://doi.org/10.1038/nature14526
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DOI: https://doi.org/10.1038/nature14526
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