Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Structural biology

Pain-sensing TRPA1 channel resolved

The TRPA1 ion channel activates pain pathways in response to noxious compounds. The structure of TRPA1 has now been solved, providing insight into how it functions. See Article p.511

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The structure of TRPA1.


  1. See all news & views


  1. Paulsen, C. E., Armache, J.-P., Gao, Y., Cheng, Y. & Julius, D. Nature 520, 511–517 (2015).

    Article  ADS  CAS  Google Scholar 

  2. Liao, M., Cao, E., Julius, D. & Cheng, Y. Nature 504, 107–112 (2013).

    Article  ADS  CAS  Google Scholar 

  3. Cao, E., Liao, M., Cheng, Y. & Julius, D. Nature 504, 113–118 (2013).

    Article  ADS  CAS  Google Scholar 

  4. Ramsey, I. S., Delling, M. & Clapham, D. E. Annu. Rev. Physiol. 68, 619–647 (2006).

    Article  CAS  Google Scholar 

  5. Julius, D. Annu. Rev. Cell Dev. Biol. 29, 355–384 (2013).

    Article  CAS  Google Scholar 

  6. Jiang, Y. et al. Nature 423, 33–41 (2003).

    Article  ADS  CAS  Google Scholar 

  7. Zhang, X. et al. Nature 486, 130–134 (2012).

    Article  ADS  CAS  Google Scholar 

  8. Payandeh, J., Gamal El-Din, T. M., Scheuer, T., Zheng, N. & Catterall, W. A. Nature 486, 135–139 (2012).

    Article  ADS  CAS  Google Scholar 

  9. Nilius, B., Appendino, G. & Owsianik, G. Pflügers Arch. 464, 425–458 (2012).

    Article  CAS  Google Scholar 

  10. Herbert, M. H., Squire, C. J. & Mercer, A. A. Viruses 7, 709–738 (2015).

    Article  CAS  Google Scholar 

  11. Suh, B.-C. & Hille, B. Annu. Rev. Biophys. 37, 175–195 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to David E. Clapham.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Clapham, D. Pain-sensing TRPA1 channel resolved. Nature 520, 439–441 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing