Molecular tracing of populations of breast-cancer cells in a primary tumour in mice reveals that two proteins, Serpine2 and Slpi, enable tumour cells to form vascular-like networks, facilitating perfusion and metastasis. See Letter p.358
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Hendrix, M. An extravascular route for tumour cells. Nature 520, 300–302 (2015). https://doi.org/10.1038/nature14382