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Race for healthy hearts

Transplantation experiments in mice reveal that the increased risk of congenital heart disease in the pups of older mothers is not conferred by ageing eggs, but by the mothers' age, and can be mitigated by exercise. See Letter p.230

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Figure 1: The maternal influence.


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  1. 1

    Miller, A., Riehle-Colarusso, T., Siffel, C., Frías, J. L. & Correa, A. Am. J. Med. Genet. A 155, 2137–2145 (2011).

    Article  Google Scholar 

  2. 2

    Ferencz, C., Rubin, J. D., Loffredo, C. A. & Magee, C. A. (eds) The Epidemiology of Congenital Heart Disease: The Baltimore-Washington Infant Study 1981–1989 (Futura, 1993).

    Google Scholar 

  3. 3

    Schulkey, C. E. et al. Nature 520, 230–233 (2015).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Lescroart, F. et al. Nature Cell Biol. 16, 829–840 (2014).

    CAS  Article  Google Scholar 

  5. 5

    De La Cruz, M. V., Giménez-Ribotta, M., Saravalli, O. & Cayré, R. Am. J. Anat. 166, 63–72 (1983).

    CAS  Article  Google Scholar 

  6. 6

    Kasahara, H., Seidman, C. E. & Izumo, S. J. Clin. Invest. 106, 299–308 (2000).

    CAS  Article  Google Scholar 

  7. 7

    Winston, J. B. et al. Circ. Cardiovasc. Genet. 5, 293–300 (2012).

    CAS  Article  Google Scholar 

  8. 8

    Padmanabhan, N. et al. Cell 155, 81–93 (2013).

    CAS  Article  Google Scholar 

  9. 9

    Ionescu-Ittu, R. et al. Br. Med. J. 338, b1673 (2009).

    Article  Google Scholar 

  10. 10

    Nitert, M. D. et al. Diabetes 61, 3322–3332 (2012).

    CAS  Article  Google Scholar 

  11. 11

    Rönn, T. et al. PLoS Genet. 9, e1003572 (2013).

    Article  Google Scholar 

  12. 12

    Mitchell, L. E. et al. Hum. Mol. Genet. 24, 265–273 (2015).

    CAS  Article  Google Scholar 

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Correspondence to Gregor Andelfinger.

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Hitz, MP., Andelfinger, G. Race for healthy hearts. Nature 520, 160–161 (2015).

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