Transplantation experiments in mice reveal that the increased risk of congenital heart disease in the pups of older mothers is not conferred by ageing eggs, but by the mothers' age, and can be mitigated by exercise. See Letter p.230
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Miller, A., Riehle-Colarusso, T., Siffel, C., Frías, J. L. & Correa, A. Am. J. Med. Genet. A 155, 2137–2145 (2011).
Ferencz, C., Rubin, J. D., Loffredo, C. A. & Magee, C. A. (eds) The Epidemiology of Congenital Heart Disease: The Baltimore-Washington Infant Study 1981–1989 (Futura, 1993).
Schulkey, C. E. et al. Nature 520, 230–233 (2015).
Lescroart, F. et al. Nature Cell Biol. 16, 829–840 (2014).
De La Cruz, M. V., Giménez-Ribotta, M., Saravalli, O. & Cayré, R. Am. J. Anat. 166, 63–72 (1983).
Kasahara, H., Seidman, C. E. & Izumo, S. J. Clin. Invest. 106, 299–308 (2000).
Winston, J. B. et al. Circ. Cardiovasc. Genet. 5, 293–300 (2012).
Padmanabhan, N. et al. Cell 155, 81–93 (2013).
Ionescu-Ittu, R. et al. Br. Med. J. 338, b1673 (2009).
Nitert, M. D. et al. Diabetes 61, 3322–3332 (2012).
Rönn, T. et al. PLoS Genet. 9, e1003572 (2013).
Mitchell, L. E. et al. Hum. Mol. Genet. 24, 265–273 (2015).
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Hitz, MP., Andelfinger, G. Race for healthy hearts. Nature 520, 160–161 (2015). https://doi.org/10.1038/nature14379
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DOI: https://doi.org/10.1038/nature14379