Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Molecular biology

RNA interference hangs by a thread

The Paf1 protein complex in fission yeast has been found to protect protein-coding genes from inhibition by RNA-mediated silencing of transcription, by stimulating the release of nascent transcripts from DNA. See Letter p.248

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Interfering with interference.


  1. 1.

    See all news & views


  1. 1

    Kowalik, K. M. et al. Nature 520, 248–252 (2015).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Sienski, G., Dönertas, D. & Brennecke, J. Cell 151, 964–980 (2012).

    CAS  Article  Google Scholar 

  3. 3

    Sigova, A., Rhind, N. & Zamore, P. D. Genes Dev. 18, 2359–2367 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Tomson, B. N. & Arndt, K. M. Biochim. Biophys. Acta Gene Reg. Mech. 1829, 116–126 (2013).

    CAS  Article  Google Scholar 

  5. 5

    Herr, A. J., Molnàr, A., Jones, A. & Baulcombe, D. C. Proc Natl Acad. Sci. USA 103, 14994–15001 (2006).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Liu, F., Bakht, S. & Dean, C. Science 335, 1621–1623 (2012).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Castel, S. E. et al. Cell 159, 572–583 (2014).

    CAS  Article  Google Scholar 

  8. 8

    Gullerova, M. & Proudfoot, N. J. Cell 132, 983–995 (2008).

    CAS  Article  Google Scholar 

  9. 9

    Zaratiegui, M. et al. Nature 479, 135–138 (2011).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Yu, R., Jih, G., Iglesias, N. & Moazed, D. Mol. Cell 53, 262–276 (2014).

    CAS  Article  Google Scholar 

  11. 11

    Nemeroff, M. E., Barabino, S. M. L., Li, Y., Keller, W. & Krug, R. M. Mol. Cell 1, 991–1000 (1998).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Mikel Zaratiegui.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zaratiegui, M. RNA interference hangs by a thread. Nature 520, 162–164 (2015).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing