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Cancer

A piece of the p53 puzzle

An iron-dependent form of cell death called ferroptosis has been implicated as a component of the tumour-suppressor activity of p53, providing fresh insight into how this protein prevents cancer development. See Article p.57

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Figure 1: The functions of p53 in tumour suppression.

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References

  1. Freed-Pastor, W. A. & Prives, C. Genes Dev. 26, 1268–1286 (2012).

    CAS  Article  Google Scholar 

  2. Jiang, L. et al. Nature 520, 57–62 (2015).

    ADS  CAS  Article  Google Scholar 

  3. Lane, D. P. Nature 358, 15–16 (1992).

    ADS  CAS  Article  Google Scholar 

  4. Vousden, K. H. & Prives, C. Cell 137, 413–431 (2009).

    CAS  Article  Google Scholar 

  5. Brady, C. A. et al. Cell 145, 571–583 (2011).

    CAS  Article  Google Scholar 

  6. Li, T. et al. Cell 149, 1269–1283 (2012).

    CAS  Article  Google Scholar 

  7. Valente, L. J. et al. Cell Rep. 3, 1339–1345 (2013).

    CAS  Article  Google Scholar 

  8. Conrad, M. & Sato, H. Amino Acids 42, 231–246 (2012).

    CAS  Article  Google Scholar 

  9. Dixon, S. J. et al. Cell 149, 1060–1072 (2012).

    CAS  Article  Google Scholar 

  10. Bieging, K. T., Mello, S. S. & Attardi, L. D. Nature Rev. Cancer 14, 359–370 (2014).

    CAS  Article  Google Scholar 

  11. Yang, W. S. et al. Cell 156, 317–331 (2014).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Laura D. Attardi.

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Bieging, K., Attardi, L. A piece of the p53 puzzle. Nature 520, 37–38 (2015). https://doi.org/10.1038/nature14374

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