Blockade of the enzyme PDE9 prevents degradation of the molecule cyclic GMP, which has been shown to protect against heart failure. The finding indicates that PDE9 inhibition might be a drug target for treating this condition. See Letter p.472
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Kuhn, M. A big-hearted molecule. Nature 519, 416–417 (2015). https://doi.org/10.1038/nature14373
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DOI: https://doi.org/10.1038/nature14373
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