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Molecular biology

Signals across domains of life

Signal sequences on messenger RNA that initiate protein synthesis are not thought to be interchangeable between life's domains. The finding that a signal from an arthropod virus can function in bacteria questions this idea. See Letter p.110

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Figure 1: Internal ribosome entry sites trigger protein synthesis in bacteria.


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  1. Malys, N. & McCarthy, J. E. G. Cell. Mol. Life Sci. 68, 991–1003 (2011).

    CAS  Article  Google Scholar 

  2. Colussi, T. M. et al. Nature 519, 110–113 (2015).

    ADS  CAS  Article  Google Scholar 

  3. Hellen, C. U. & Sarnow, P. Genes Dev. 15, 1593–1612 (2001).

    CAS  Article  Google Scholar 

  4. Bonning, B. C. & Miller, W. A. Annu. Rev. Entomol. 55, 129–150 (2010).

    CAS  Article  Google Scholar 

  5. Wilson, J. E., Pestover, C. V., Hellen, C. U. & Sarnow, P. Cell 102, 511–520 (2000).

    CAS  Article  Google Scholar 

  6. Fernández, I. S., Bai, X. C., Murshudov, G., Scheres, S. H. & Ramakrishnan, V. Cell 157, 823–831 (2014).

    Article  Google Scholar 

  7. Pfingsten, J. S., Costantino, D. A. & Kieft, J. S. Science 314, 1450–1454 (2006).

    ADS  CAS  Article  Google Scholar 

  8. Breaker, R. R. Cold Spring Harb. Perspect. Biol. 4, 003566 (2012).

    Article  Google Scholar 

  9. Moll, I., Grill, S., Gualerzi, C. O. & Bläsi, U. Mol. Microbiol. 43, 239–246 (2002).

    CAS  Article  Google Scholar 

  10. Nishiyama, T., Yamamoto, H., Uchiumi, T. & Nakashima, N. Nucleic Acids Res. 35, 1514–1521 (2007).

    CAS  Article  Google Scholar 

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Correspondence to Eric Jan.

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Jan, E. Signals across domains of life. Nature 519, 40–41 (2015).

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