Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell biology

Death drags down the neighbourhood

An analysis of dying cells reveals that they play an active part in modifying tissue shape by pulling on neighbouring cells. This induces neighbouring cells to contract at their apices, which results in tissue folding. See Letter p.245

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Apoptosis and fold formation.

Notes

  1. See all news & views

References

  1. Baehrecke, E. H. Nature Rev. Mol. Cell Biol. 3, 779–787 (2002).

    CAS  Article  Google Scholar 

  2. Monier, B. et al. Nature 518, 245–248 (2015).

    ADS  CAS  Article  Google Scholar 

  3. Rosenblatt, J., Raff, M. C. & Cramer, L. P. Curr. Biol. 11, 1847–1857 (2001).

    CAS  Article  Google Scholar 

  4. Lubkov, V. & Bar-Sagi, D. Curr. Biol. 24, 868–874 (2014).

    CAS  Article  Google Scholar 

  5. Manjón, C., Sánchez-Herrero, E. & Suzanne, M. Nature Cell Biol. 9, 57–63 (2007).

    Article  Google Scholar 

  6. Dawes-Hoang, R. E. et al. Development 132, 4165–4178 (2005).

    CAS  Article  Google Scholar 

  7. Manning, A. J., Peters, K. A., Peifer, M. & Rogers, S. L. Sci. Signal. 6, ra98 (2013).

    Article  Google Scholar 

  8. Farhadifar, R., Röper, J.-C., Aigouy, B., Eaton, S. & Jülicher, F. Curr. Biol. 17, 2095–2104 (2007).

    CAS  Article  Google Scholar 

  9. Fernandez-Gonzalez, R., de Matos Simoes, S., Röper, J., Eaton, S. & Zallen, J. A. Dev. Cell 17, 736–743 (2009).

    CAS  Article  Google Scholar 

  10. Pouille, P.-A., Ahmadi, P., Brunet, A.-C. & Farge, E. Sci. Signal. 2, ra16 (2009).

    Article  Google Scholar 

  11. Ren, Y. et al. Curr. Biol. 19, 1421–1428 (2009).

    CAS  Article  Google Scholar 

  12. Vasquez, C. G., Tworoger, M. & Martin, A. C. J. Cell Biol. 206, 435–450 (2014).

    CAS  Article  Google Scholar 

  13. Herrgen, L., Voss, O. P. & Akerman, C. J. Dev. Cell 31, 599–613 (2014).

    CAS  Article  Google Scholar 

  14. Toyama, Y., Peralta, X. G., Wells, A. R., Kiehart, D. P. & Edwards, G. S. Science 321, 1683–1686 (2008).

    ADS  CAS  Article  Google Scholar 

  15. Odell, G. M., Oster, G., Alberch, P. & Burnside, B. Dev. Biol. 85, 446–462 (1981).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Adam C. Martin.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Vasquez, C., Martin, A. Death drags down the neighbourhood. Nature 518, 171–173 (2015). https://doi.org/10.1038/nature14198

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature14198

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing