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Elusive source of sulfur unravelled

The metabolic origin of the sulfur atom in the naturally occurring antibiotic lincomycin A has been obscure — until now. The biosynthetic steps involved reveal surprising roles for two sulfur-containing metabolites. See Letter p.115

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Figure 1: Biosynthesis of lincomycin A.


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  1. Ahlert, J. et al. Science 297, 1173–1176 (2002).

    CAS  Article  ADS  Google Scholar 

  2. Tang, G. L, Cheng, Y. Q. & Shen, B. Chem. Biol. 11, 33–45 (2004).

    CAS  Article  Google Scholar 

  3. Zeng, Y. et al. ACS Chem. Biol. 7, 1565–1575 (2012).

    CAS  Article  Google Scholar 

  4. Zhao, Q., Wang, M., Xu, D., Zhang, Q & Liu, W. Nature 518, 115–119 (2015).

    CAS  Article  ADS  Google Scholar 

  5. Chatterjee, A. et al. Nature 478, 542–546 (2011).

    CAS  Article  ADS  Google Scholar 

  6. Sasaki, E. et al. Nature 510, 427–430 (2012).

    Article  ADS  Google Scholar 

  7. Čermák, L. et al. Folia Microbiol. 52, 457–462 (2007).

    Article  Google Scholar 

  8. Kadlčik, S. et al. PLoS ONE 8, e84902 (2013).

    Article  ADS  Google Scholar 

  9. Sasaki, E., Lin, C.-I., Lin, K.-Y. & Liu, H. J. Am. Chem. Soc. 134, 17432–17435 (2012).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Charles E. Melançon III.

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Melançon, C. Elusive source of sulfur unravelled. Nature 518, 45–46 (2015).

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