The metabolic origin of the sulfur atom in the naturally occurring antibiotic lincomycin A has been obscure — until now. The biosynthetic steps involved reveal surprising roles for two sulfur-containing metabolites. See Letter p.115
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Ahlert, J. et al. Science 297, 1173–1176 (2002).
Tang, G. L, Cheng, Y. Q. & Shen, B. Chem. Biol. 11, 33–45 (2004).
Zeng, Y. et al. ACS Chem. Biol. 7, 1565–1575 (2012).
Zhao, Q., Wang, M., Xu, D., Zhang, Q & Liu, W. Nature 518, 115–119 (2015).
Chatterjee, A. et al. Nature 478, 542–546 (2011).
Sasaki, E. et al. Nature 510, 427–430 (2012).
Čermák, L. et al. Folia Microbiol. 52, 457–462 (2007).
Kadlčik, S. et al. PLoS ONE 8, e84902 (2013).
Sasaki, E., Lin, C.-I., Lin, K.-Y. & Liu, H. J. Am. Chem. Soc. 134, 17432–17435 (2012).
About this article
Cite this article
Melançon, C. Elusive source of sulfur unravelled. Nature 518, 45–46 (2015). https://doi.org/10.1038/nature14197