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Seeking ultimate victory

HIV variants that have mutated to escape T-cell immune responses dominate the latent viral reservoir in most patients on antiretroviral therapy. This finding will need to guide therapeutic approaches targeting reactivated virus. See Letter p.381

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Figure 1: Immune escape complicates targeting of the HIV reservoir.


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Correspondence to Louis J. Picker or Jeffrey D. Lifson.

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Picker, L., Lifson, J. Seeking ultimate victory. Nature 517, 281–282 (2015).

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