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Cell biology

On the endocytosis rollercoaster

Endocytosis is a process by which molecules gain access to a cell. An unusual mode of endocytosis has now been shown to regulate cell signalling, and to be highjacked by bacterial toxins. See Article p.460 & Letter p.493

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Figure 1: Mechanisms of endocytosis.


  1. Doherty, G. J. & McMahon, H. T. Annu. Rev. Biochem. 78, 857–902 (2009).

    Article  CAS  Google Scholar 

  2. Howes, M. T., Mayor, S. & Parton, R. G. Curr. Opin. Cell Biol. 22, 519–527 (2010).

    Article  CAS  Google Scholar 

  3. Boucrot, E. et al. Nature 517, 460–465 (2015).

    Article  ADS  CAS  Google Scholar 

  4. Renard, H.-F. et al. Nature 517, 493–496 (2015).

    Article  ADS  CAS  Google Scholar 

  5. Römer, W. et al. Cell 140, 540–553 (2010).

    Article  Google Scholar 

  6. Lamaze, C. et al. Mol. Cell 7, 661–671 (2001).

    Article  CAS  Google Scholar 

  7. Milosevic, I. et al. Neuron 72, 587–601 (2011).

    Article  CAS  Google Scholar 

  8. Tang, Y. et al. Proc. Natl Acad. Sci. USA 96, 12559–12564 (1999).

    Article  ADS  CAS  Google Scholar 

  9. Soubeyran, P., Kowanetz, K., Szymkiewicz, I., Langdon, W. Y. & Dikic, I. Nature 416, 183–187 (2002).

    Article  ADS  CAS  Google Scholar 

  10. Petrelli, A. et al. Nature 416, 187–190 (2002).

    Article  ADS  CAS  Google Scholar 

  11. Kononenko, N. L. et al. Neuron 82, 981–988 (2014).

    Article  CAS  Google Scholar 

  12. Bitsikas, V., Correa, I. R. & Nichols, B. J. eLife 3, e03970 (2014);

    Article  Google Scholar 

  13. Posor, Y. et al. Nature 499, 233–237 (2013).

    Article  ADS  CAS  Google Scholar 

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Correspondence to Volker Haucke.

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Haucke, V. On the endocytosis rollercoaster. Nature 517, 446–447 (2015).

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