Extended Data Figure 4 : Workflow of bioinformatic procedures and experimental rationale for the entire study.

From: Radial glia require PDGFD–PDGFRβ signalling in human but not mouse neocortex

Extended Data Figure 4

The bioinformatic component of this study sought to identify a homologous gene co-expression signature for human and mouse RG that is robust across multiple sampling strategies/technology platforms and can be normalized to facilitate comparisons within and between species. This pipeline illustrates the steps that were taken to identify, integrate and compare RG gene co-expression signatures in eight transcriptomic data sets generated from prenatal human and mouse neocortex.